实验室研究方向

　　硒资源研究与生物应用湖北省重点实验室瞄准硒科学发展前沿，深化硒的基础研究，强化硒的应用研究。立足资源优势，开展"硒与大健康"的科研攻关，寻求硒资源高效、安全利用的科学依据，促进硒的科研成果转化，探索硒的"产学研用"系统合作模式，突破硒产业发展的关键瓶颈，推动高校与地方经济社会深度融合，提升硒资源附加值，助力硒产业持续健康发展。实验室拟设置五个研究方向：硒的循环调控与高效利用、富硒种质资源的培育与改良、硒的检测技术与标准体系研发、富硒产品的开发与功能评价及硒与人体健康研究。

　　1.硒的循环调控与高效利用

　　立足恩施硒资源优势，研究地表环境中硒的空间分布、赋存形态、迁移转化、生物有效性及综合利用；科学调控土壤、植物、水体等圈层中硒的赋存形态和迁移转化行为，培育绿色富硒农产品，提升硒资源附加值，促进硒产业持续健康发展。研究内容如下：

　　(1)硒的赋存形态和迁移转化

　　(2)立足硒资源优势开拓硒资源基地

　　(3)不同形态硒对重金属的拮抗效应

　　(4)不同形态硒与营养元素的协同作用

　　(5)基于硒的迁移转化调控培育富有机硒农产品

　　2.富硒种质资源的培育与改良

　　利用最新生物化学与分子生物学的方法，进一步厘清不同类型生物体内硒的代谢网络，弄清硒蛋白的生物合成及调控的分子机理，为硒生物学功能方面的研究奠定理论基础。研究内容如下：

　　(1)特色硒生物种质资源收集、筛选和利用评价

　　(2)微生物、动物、植物的硒代谢网络构建

　　(3)硒蛋白生物合成及调控的分子机理

　　(4)微生物纳米硒工程

　　(5)高产硒蛋白微生物的筛选及富硒工程研究

　　3.硒的检测技术与标准体系研发

　　基于现行有机硒含量测定的标准存在富硒产品的效果评价不准确、现行测定方法难以全面开展富硒产品普查工作、产品的硒形态检测标准的科学依据不充分、各类疾病人群和亚健康人群的硒补充基础标准缺乏、不同形态硒对动植物和人体的安全标准欠缺等问题，围绕硒形态分析检测、富硒种养殖标准化、硒产品质量控制标准化、有机硒化合物标准物质库的建立，解决当前硒产品检测和标准体系建设中的关键技术问题，推动硒产业的健康发展。研究内容如下：

　　(1)建立有机硒化合物标准库

　　(2)构建有机硒分析测试方法体系

　　(3)硒专用离子体射流固体烧蚀光谱仪研发及硒元素的检测

　　4.富硒产品的开发与功能评价

　　为湖北打造高知名度的农产品，推动硒产业持续健康发展，专注于硒食品的营养与安全性评价及富硒农产品精深加工与智能制造研究，为硒食品精深加工提供理论和技术支撑。重点焦聚产业端标准化、差异化和高端化的技术需求，瞄准基于硒形态的稳态转化富集及基于功能的构效关系，实现湖北特色富硒生物资源基础研究与产业转化的无缝衔接。研究内容如下：

　　(1)富硒生物资源硒形态研究

　　(2)恩施特色食药同源富硒资源挖掘与利用

　　(3)富硒生物资源营养健康功效评价及产品开发

　　5.硒与人体健康

　　焦聚湖北省"硒与大健康"产业发展关键瓶颈问题，开展硒对人体健康影响机制的理论与应用研究。调查我国不同地区硒的背景值和特定人群流行病，构建动物疾病模型，阐明硒-硒蛋白的免疫调控机制，明确补硒对免疫相关性疾病(自身免疫性疾病、感染、肿瘤等)的干预机制，解决湖北省硒产业科技支撑体系不完善的关键问题，打造医疗转化中心，促进硒产业向高附加值的医药产业转化，为"硒与大健康"的战略发展提供科学依据和可行方案。研究内容如下：

　　(1)硒与脂质泛氧化相关疾病

　　(2)硒蛋白小分子抑制剂与抗肿瘤治疗

　　(3)硒预防非酒精性脂肪性肝炎(NASH)的作用

　　(4)硒与自身免疫性疾病等的关系

Research Directions

The Hubei Key Laboratory of Selenium Resources Research and Biological Application advances selenium science through fundamental research and applied innovations. Leveraging regional advantages of selenium resources, we pioneer "Selenium and Human Health" initiatives to establish scientific foundations for efficient and safe selenium utilization, accelerate translational outcomes, and develop academia-research-application-industry integration models. Our mission targets critical bottlenecks in selenium industry development while fostering university-regional socioeconomic synergy to enhance selenium resource value. The laboratory operates through five interconnected research directions:

1. Selenium Cycling Regulation and Efficient Utilization

Based on Enshi’s selenium-rich resources to study spatial distribution, speciation, migration, bioavailability, and comprehensive utilization of selenium in surface environments.

Research Focus:

(1) Speciation analysis and biogeochemical cycling of selenium

(2) Strategic development of selenium resource bases

(3) Antagonistic effects of selenium species against heavy metals

(4) Synergistic interactions between selenium species and essential nutrients

(5) Cultivation of organoselenium-enriched crops via migration regulation

2. Selenium-Enriched Germplasm Breeding and Improvement

Elucidating selenium metabolic networks and selenoprotein biosynthesis mechanisms using biochemistry and molecular biology approaches, laying a theoretical foundation for the study of the biological function of selenium.

Research Focus:

(1) Collection, screening, and evaluation of unique selenium-enriched germplasm

(2) Construction of microbial/plant/animal selenium metabolic networks

(3) Molecular mechanisms of selenoprotein synthesis and regulation

(4) Engineering of microbial nanoselenium production

(5) Screening of high-yield selenoprotein microorganisms

3. Selenium Detection Technologies and Standardization Systems

Current limitations in organic selenium quantification standards compromise accurate efficacy assessment of selenium-enriched products, hinder comprehensive product surveys, and lack sufficient scientific basis for speciation analysis. Critical gaps persist in establishing foundational supplementation guidelines for diseased/sub-healthy populations and safety standards for various selenium species in biological systems.

To address these challenges, our research focuses on developing advanced selenium speciation analytical platforms, standardized cultivation protocols for selenium-enriched agriculture, quality control frameworks for selenium products and certified reference material libraries for organoselenium compounds. These integrated solutions target key technological bottlenecks in selenium product evaluation and standardization systems, ultimately promoting sustainable industry development.

Research Focus:

(1) Establishing certified reference material libraries for organoselenium compounds

(2) Developing advanced analytical methodologies for selenium speciation

(3) Innovating plasma jet solid ablation spectrometry for selenium detection

4. Development and Functional Evaluation of Selenium-Enriched Products

To establish premium agricultural brands for Hubei and advance sustainable development of the selenium industry, our research prioritizes nutritional and safety assessment of selenium-enriched foods, and precision processing and intelligent manufacturing systems for selenium bioresources. We aim to establish industrial transformation framework for standardization of production protocols, differentiation strategies for high-value products, premiumization through quality certification. Our core technological innovations focus on:

(1) Selenium speciation-based enrichment: Controlling steady-state conversion during processing

(2) Structure-activity relationship studies: Linking molecular forms to biological functions

These initiatives bridge fundamental research on Hubei's unique selenium-rich resources with industrial applications, creating seamless knowledge-to-industry pipelines for value-added selenium products.

Research Focus:

(1) Speciation analysis of selenium in biological resources

(2) Exploitation of Enshi’s medicinal-food homologous selenium resources

(3) Health efficacy evaluation and product development of selenium bioresources

5. Selenium and Human Health

Focused on critical bottlenecks in Hubei's "Selenium and Health" industry, we conduct theoretical and applied research on selenium's impact on human health. Our integrated approach involves:

(1) Epidemiological Mapping:

National survey of selenium background values across biogeochemical regions

Cohort studies targeting selenium status in immunocompromised populations

(2) Mechanistic Investigation:

Development of disease-specific animal models (autoimmunity/infection/oncology)

Elucidation of selenium-selenoprotein immunomodulatory networks

Intervention mechanisms of selenium supplementation in immune-related pathologies

(3) Translational Implementation:

Establishment of a medical translation center bridging research and clinical practice

Development of high-value pharmaceutical applications for selenium compounds

Evidence-based strategies for "Selenium and Health" strategic implementation

This research addresses deficiencies in Hubei's selenium industry support system while providing scientific foundations for precision nutrition guidelines, selenium-based therapeutics development, and industrial transformation roadmap

Research Focus:

(1) Selenium intervention in lipid peroxidation-related diseases

(2) Selenoprotein-targeted small molecule inhibitors for anticancer therapy

(3) Protective mechanisms of selenium against non-alcoholic steatohepatitis (NASH)

(4) Selenium modulation of autoimmune diseases